Immunochromatography screening devices for cannabinoids in oral fluid sample
نویسندگان
چکیده
Cannabis sativa L. is one of the most consumed drugs in world and recent studies have associated its use with an increase number traffic accidents different countries. In many countries, like Brazil, simple reliable methodologies are still needed for detection on site, mainly cannabinoids, considering prevalence oral fluid (OF) has been proved as appropriate biological matrix this purpose. Considering that, work aims to review previous immunochromatographic devices on-site cannabinoids OF, discussing their sensitivity, specificity, cut-offs values confirmatory methods. This data shows importance choosing a screening device it reinforces need implementation Brazil. The research was conducted 5 databases all original articles, published last 10 years, were selected. A total 32 articles found, providing 17 distinct brands. Only 2 showed satisfactory sensitivity specificity evaluated (≥80% ≥90% respectively). However, should be considered that some limitations, such higher cut-off than those recommended by international guidelines (cut-off > ng/mL), therefore demonstrating more area analysis usually fulfilled LC-MS/MS, GC-MS/MS or GC-MS. Thus, analyzes not itself, but association results observational traits (behavioral changes), better understanding scenario.
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ژورنال
عنوان ژورنال: Brazilian Journal of Pharmaceutical Sciences
سال: 2023
ISSN: ['2175-9790', '1984-8250']
DOI: https://doi.org/10.1590/s2175-97902023e20555